Some of the chemicals used in medical treatments can damage the lungs, while others may be more harmful, according to new research.
The National Toxicology Program (NTP) announced Thursday that it had found the chemicals in more than 200 clinical trials and studies over the past decade.
It said the number of new chemicals in clinical trials has quadrupled over the last decade, reaching almost 10,000 since 2000.
The number of clinical studies is believed to be much higher.
Researchers say there is no one chemical that can cause death from inhalation of any chemical.
But the compounds used in treatments may cause cancer, respiratory problems and death.
The new study, conducted by the University of California at San Diego, was based on data from a review of more than 1,200 clinical trials from the past 10 years.
It found more than 2,500 compounds had been found to be toxic to humans and animal cells in the clinical trials.
Among them are:Acetaminophen (prescription and over-the-counter pain medication)Clorox (pain reliever)Cocoa oil(oil made from cocoa beans)Diclofenac (antibiotic pain reliever)Lipitor (antidepressant)Nardil (anti-cancer drug)Vitamin C (essential fatty acid)Other compounds found in clinical studies included the chemical diclopride, a commonly used painkiller, and benzylpiracetam, a chemical used to treat depression.NTP said the research revealed that while some of the compounds have been found in more recent clinical trials, others were not yet found in many studies.
For instance, the chemical neopentylpyridine, which was found in a study in 2012, was not in a clinical trial for its ability to inhibit lung cancer growth.
A review of data from previous studies found that some compounds in the U.S. market, including benzylbutazone, a common cancer drug, and a popular anti-depressant, methylphenidate, have been linked to respiratory damage, including bronchial asthma and respiratory failure.
“While the findings of the NTP study may not be completely reassuring, it is the first to quantify the extent to which the risks associated with these compounds may have increased over the course of the past two decades,” said the report, which reviewed data from the FDA and the EPA and other federal agencies.
The report also found that compounds with similar toxicological profiles have been used for decades, and that there were numerous different compounds used as ingredients in medical products.
In a statement, the FDA said it is working to update the agency’s regulatory system to reflect the latest scientific evidence.
“The FDA has taken a number of actions to address the increasing number of compounds and chemical compounds that may be toxic,” said agency spokeswoman Jessica Richman.
“These actions include the establishment of the new Toxicological Safety Advisory Committee to provide public input on the future of these compounds.”
The FDA is also working to improve the FDA’s website to include information about toxicology, toxicity and other information on the products.